| 产品详情 |
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| Product Name | LDN-214117 |
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| Description | Purity >98%. Bone morphogenetic proteins (BMPs) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation. Activation of BMP type I receptors, also known as activin receptor-like kinases (ALK1-7), leads to the assembly of SMAD complexes, which translocate to the nucleus to induce transcriptional activation important for normal development and tissue repair. LDN-214117 is a selective BMP type I receptor kinase ALK1 and ALK2 inhibitor (IC50 s = 24 nM for each). It demonstrates preference for ALK1 and ALK2 over ALK3 (IC50 = 1.17 µM) and other related activin and TGF-Beta type I receptors (IC50 s = 3, 0.1, and 16 µM for ALK5, BMP6, and TGF-Beta, respectively). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]-piperazine |
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| Gene, Accession, CAS # | CAS: 1627503-67-6 |
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| Catalog # | LS-H8437 |
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| Order / More Info | LDN-214117 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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