| 产品详情 |
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| Product Name | LDN-57444 |
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| Description | Purity >95%. The ubiquitin C-terminal hydrolase L1 (UCH-L1) is a member of a family of de-ubiquitinating enzymes that can generate free ubiquitin from ubiquitin precursors via its ubiquitin ligase activity. By associating with free ubiquitin, it also prevents its degradation. Neuronal UCH-L1 has been linked to Parkinson's disease, the development of tumors, and neuropathic pain. LDN-57444 is an inhibitor of UCH-L1 activity (IC50 = 0.88, Ki = 0.4 µM) that demonstrates selectivity for UCH-L1 compared to UCH-L3 (IC50 = 25 µM). Loss of UCH-L1 activity causes cell death through the apoptosis pathway due to an impaired ubiquitin-proteasome pathway. LDN-57444-induced reduction of free ubiquitin has been shown to create dramatic alterations in synaptic structure and function, increasing spine size while decreasing spine density in hippocampal neurons. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime), Ubiquitin C-terminal Hydrolase L1 Inhibitor, UCH-L1 Inhibitor |
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| Gene, Accession, CAS # | CAS: 668467-91-2 |
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| Catalog # | LS-H8439 |
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| Order / More Info | LDN-57444 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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