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| Product Name | LE 135 |
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| Description | Purity >98%. LE 135 is a retinoic acid receptor (RAR) antagonist that displays moderate selectivity for RARBeta over RARAlpha (Ki s = 0.22 and 1.4 µM, respectively). LE 135 inhibits retinoic acid-induced transcriptional activation of RARBeta (>70% inhibition at 10 µM), but not RARAlpha, RARGamma or retinoid X receptor Alpha. It has been shown to inhibit retinoid Am80-induced differentiation of human promyelocytic leukemia cells, HL-60, with an IC50 value of 0.2 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)-benzoic acid |
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| Gene, Accession, CAS # | CAS: 155877-83-1 |
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| Catalog # | LS-H8440 |
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| Price | |
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| Order / More Info | LE 135 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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