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| Product Name | PD-1 / Fc Chimera Protein (Recombinant) |
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| Description | Purity >98% by SDS-PAGE, MW: 60-65 kDa (SDS-PAGE). Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279) or PDCD1, is a protein that in humans is encoded by the PDCD1 gene. PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells.PD-1 binds two ligands, PD-L1 and PD-L2. PD-1 and its ligands play an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells) Recombinant Human PD-1 produced in CHO cells with C-terminal Fc tag, is a polypeptide chain containing 376 amino acids. A fully biologically active molecule, rhPD-1 has a molecular mass of 60-65 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques. |
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| Size | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-G27024 |
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| Order / More Info | PD-1 / Fc Chimera Protein (Recombinant) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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