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| Product Name | FRAX597 |
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| Description | Purity >98% by HPLC. FRAX597 is a potent group I PAK (p21-activated kinase) inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). Displays significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 >10 MM for PAK4). FRAX597 inhibits the proliferation of NF2-deficient schwannoma cells in culture and displays potent anti-tumor activity in vivo. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one |
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| Gene, Accession, CAS # | CAS: 1286739-19-2 |
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| Catalog # | LS-H4297 |
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| Order / More Info | FRAX597 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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