| 产品详情 |
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| Product Name | JZL195 |
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| Description | Purity >98% by HPLC. JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) (IC50 = 2 nM) and fatty acid amide hydrolase (FAAH) (IC50 = 4 nM), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester |
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| Gene, Accession, CAS # | CAS: 1210004-12-8 |
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| Catalog # | LS-H3776 |
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| Order / More Info | JZL195 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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