| 产品详情 |
| Edit |   |
|---|
| Product Name | 8-pCPT-2'-O-Me-Cyclic AMP (sodium salt) |
|---|
| Description | Purity >98%. Exchange proteins activated by cAMP (Epacs) are guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-pCPT-2'-O-Me-Cyclic AMP is an 8-(4-chlorophenylthio) analog of cAMP that activates Epacs (AC50 = 1.8 µM). It is a super-activator of Epacs in that it dissociates GDP from Rap1 more strongly than the natural Epac agonist, cAMP. 8-pCPT-2'-O-Me-cAMP is strongly selective for Epac over the cAMP-activated kinase PKA. It does not discriminate between Epac1 and Epac2 and is used extensively to elucidate the roles of these Rap GEFs in cell function. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 8-[(4-chlorophenyl)thio]-2'-O-methyl-adenosine cyclic 3',5'-(hydrogen phosphate), monosodium salt, 8-CPT-2Me-cAMP, 8-pCPT-2?-O-Me-cAMP, 8-pCPT-cAMP |
|---|
| Gene, Accession, CAS # | CAS: 634207-53-7 |
|---|
| Catalog # | LS-H6314 |
|---|
| Price | |
|---|
| Order / More Info | 8-pCPT-2'-O-Me-Cyclic AMP (sodium salt) from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|