| 产品详情 |
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| Product Name | STK393606 |
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| Description | Purity >98%. 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH) is a key enzyme involved in the inactivation of PGs and related eiscosanoids. It functions by catalyzing the oxidation of primary PGs to their 15-keto metabolites. Two types of 15-hydroxy PGDH have been identified: type-I is NAD+ -dependent primarily using eicosanoids as substrates, while type-II uses either NAD+ or NADP+ as cofactors and bears broader substrate specificity. STK393606 is a competitive inhibitor of NAD+ -dependent type-I 15-hydroxy PGDH with an IC50 value of 26.4 nM and a Ki value of 5 nM. It demonstrates selectivity for 15-hydroxy PGDH when profiled across a panel of related dehydrogenase or reductase enzymes. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[[(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)thio]methyl]-benzonitrile |
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| Gene, Accession, CAS # | CAS: 355827-05-3 |
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| Catalog # | LS-H10049 |
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| Price | |
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| Order / More Info | STK393606 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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