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| Product Name | WYE-354 |
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| Description | Purity >98%. WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of phosphatidylinositol 3-kinase Alpha (IC50 = 1026 nM) and other kinases. WYE-354 induces G1 cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines, inhibits mTORC1 and mTORC2 in tumor-bearing mice, and reduces tumor growth in nude mice with PTEN-null tumors. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[6-[4-[(methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-methyl ester-1-piperidinecarboxylic acid |
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| Gene, Accession, CAS # | CAS: 1062169-56-5 |
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| Catalog # | LS-H10510 |
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| Order / More Info | WYE-354 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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