| 产品详情 |
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| Product Name | WZB117 |
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| Description | Purity >98%. WZB117 is an irreversible inhibitor of glucose transporter 1 (Glut1) that blocks glucose transport in diverse cancer cells (IC50 = ~0.6 µM), reducing extracellular lactate and intracellular ATP levels. It inhibits cancer cell proliferation (IC50 s = 5-10 µM), resulting in cell cycle arrest, senescence, and necrosis or apoptosis. These effects are enhanced by the anticancer drugs cisplatin and paclitaxel . WZB117, given intraperitoneally at 10 mg/kg, significantly reduces tumor size in mice, with only small reductions in body weight and leukocyte count. WZB117 also inhibits the self-renewal and tumor-initiating capacity of cancer stem cells, blocking tumor initiation after implantation of cancer stem cells in mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-hydroxy-benzoic acid, (3-fluoro-1,2-phenylene)ester, Glucose Transporter Inhibitor IV |
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| Gene, Accession, CAS # | CAS: 1223397-11-2 |
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| Catalog # | LS-H10513 |
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| Order / More Info | WZB117 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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