| 产品详情 |
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| Product Name | XEN445 |
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| Description | Purity >98%. Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as a substrate. XEN445 is an endothelial lipase inhibitor (IC50 = 237 nM) that demonstrates selectivity for endothelial lipase compared to lipoprotein and hepatic lipases (IC50 s = 20 and 9.5 µM, respectivley). An oral dose of 30 mg/kg XEN445 is reported to increase HDL cholesterol concentrations by 16% after three days and by 30% after nine days dosing in wild-type mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[(3S)-3-(2-pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)-benzoic acid |
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| Gene, Accession, CAS # | CAS: 1515856-92-4 |
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| Catalog # | LS-H10523 |
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| Price | |
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| Order / More Info | XEN445 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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