| 产品详情 |
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| Product Name | TUG-891 |
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| Description | Purity >97%. GPR120 (free fatty acid receptor 4; FFAR4) is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids. Omega-3 Fatty acids, such as docosahexaenoic acid and eicosapentaenoic acid, initiate GPR120 signaling resulting in inhibition of toll-like receptor and TNF- alpha inflammatory signaling pathways in a beta -arrestin2/TAB1 dependent manner. TUG-891 is a potent and selective agonist of GPR120 with pEC50 values of 7.36 and 7.77 for human and mouse GPR120, respectively. It activates GPR40 (FFAR1) with a pEC50 value of 4.19 and shows no activity at GPR41 (FFAR3) or GPR43 (FFAR2). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid |
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| Gene, Accession, CAS # | CAS: 1374516-07-0 |
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| Catalog # | LS-H131 |
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| Price | |
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| Order / More Info | TUG-891 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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