| 产品详情 |
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| Product Name | Latrunculin A |
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| Description | Purity >98%. Actin disruption is used to study cell functions in vitro (e.g., migration, endocytosis) and in vivo (e.g., tumor cell invasion). Latrunculin A is a bioactive 2-thiazolidinone macrolide derived from sponges that sequesters G-actin and prevents F-actin assembly. It binds monomeric actin with 1:1 stoichiometry and can be used to block actin polymerization both in vitro (Kd = 0.2 µM) and in cells (0.5 µM, 30 min). Latrunculin A (1-10 µM) causes depolymerization of tumor cell cytoskeleton within ten minutes. Overnight treatment of cells with latrunculin A (10 µM) strongly suppresses actin synthesis. Prolonged cell treatment blocks dexamethasone-induced changes in actin cytoskeleton with no effect on cell viability. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (4R)-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone, NSC 613011 |
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| Gene, Accession, CAS # | CAS: 76343-93-6 |
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| Catalog # | LS-H8413 |
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| Order / More Info | Latrunculin A from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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