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| Product Name | 3-bromo-5-phenyl Salicylic Acid |
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| Description | Purity >95%. The aldo-keto reductase (AKR) enzymes constitute a family of related NADPH-dependent oxidoreductases. The 1 C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases, with AKR1C1 being a 20Alpha-HSD and the other three being 3Alpha-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20Alpha-hydroxy progesterone. In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function. 3-bromo-5-phenyl Salicylic acid selectively inhibits AKR1C1 (Ki = 4 nM) over AKR1C2 (Ki = 87 nM), AKR1C3 (Ki = 4.2 µM), and AKR1C4 (Ki = 18.2 µM). Moreover, it potently inhibits the metabolism of progesterone by bovine aortic endothelial cells overexpressing AKR1C1 (IC50 = 460 nM). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-bromo-4-hydroxy-[1,1'-biphenyl]-3-carboxylic acid, NSC 109116 |
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| Gene, Accession, CAS # | CAS: 4906-68-7 |
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| Catalog # | LS-H6049 |
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| Order / More Info | 3-bromo-5-phenyl Salicylic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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