| 产品详情 |
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| Product Name | 5-bromo-3-phenyl Salicylic Acid |
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| Description | Purity >95%. The aldo-keto reductase (AKR) enzymes constitute a family of related NADP-dependent oxidoreductases. The 1C subfamily (AKR1C) includes four human hydroxysteroid dehydrogenases (HSD), with AKR1C1 being a 20Alpha-HSD and the other three being 3Alpha-HSDs. AKR1C1 metabolizes progesterone to an inactive progestin, 20Alpha-hydroxy progesterone. In addition, AKR1C1 actions have been implicated in cancer and in the processing of neuroactive steroids involved in brain function. 5-bromo-3-phenyl Salicyclic acid selectively inhibits AKR1C1 (Ki = 140 nM) over AKR1C2 (K1 = 1.97 µM) and AKR1C3 (Ki = 21 µM). It does not inhibit AKR1C4 at 100 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-bromo-2-hydroxy-[1,1'-biphenyl]-3-carboxylic acid |
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| Gene, Accession, CAS # | CAS: 99514-99-5 |
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| Catalog # | LS-H6198 |
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| Order / More Info | 5-bromo-3-phenyl Salicylic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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