| 产品详情 |
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| Product Name | CP 80,633 |
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| Description | Purity >95%. Phosphodiesterases (PDE) enzymatically convert the cyclic nucleotide second messengers cAMP and cGMP to 5'-AMP and 5'-GMP, respectively, thus terminating signal transduction. The cAMP-specific PDE4 isoforms may be particularly important in certain respiratory and neurological diseases. CP 80,633 is a selective inhibitor of PDE4 (IC50 = 1.27 µM for PDE4 versus . >100 µM for PDE1, PDE2, PDE3, and PDE5). It potentiates PGE1 -dependent increases in cAMP levels in eosinophils, monocytes, and T-cells, inhibits eosinophil superoxide production (IC50 < 0.6 µM), and blocks LPS-induced TNF-Alpha release from monocytes (IC50 = 0.22 µM). CP 80,633 (1 mg/kg) significantly reduces antigen-induced airway inflammation in atopic guinea pigs, monkeys, and mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-methoxyphenyl]tetrahydro-2-(1H)-pyrimidinone |
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| Gene, Accession, CAS # | CAS: 135637-46-6 |
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| Catalog # | LS-H7250 |
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| Price | |
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| Order / More Info | CP 80,633 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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