| 产品详情 |
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| Product Name | BYL719 |
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| Description | Purity >98%. BYL719 is a selective inhibitor of phosphoinositide 3-kinase Alpha (PI3KAlpha) that is equipotent against both wild type and several mutant isoforms (IC50 s = 4.0-4.8 nM). It is less effective against PI3K isoforms Beta, Gamma, and Delta (IC50 s = 1,156, 250, and 290 nM) as well as a range of related kinases. BYL719 is effective in vivo, as it dose-dependently inhibits the growth of PI3KAlpha-dependent xenograft tumors in mice. Effectiveness against wild type and mutant PI3KAlpha-dependent tumors may be augmented by combination therapy with inhibitors of other kinases. Combination therapy may be necessary, as loss of downstream pathway components can confer clinical resistance to BYL719. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2S)-N1 -[4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethylethyl)-4-pyridinyl]-2-thiazolyl]-1,2-pyrrolidinedicarboxamide, Alpelisib, NVP-BYL719 |
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| Gene, Accession, CAS # | CAS: 1217486-61-7 |
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| Catalog # | LS-H6940 |
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| Price | |
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| Order / More Info | BYL719 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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