| 产品详情 |
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| Product Name | CRT5 |
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| Description | Purity >98%. Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50 s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). It has little effect on a panel of additional kinases when given at 1 µM. CRT5 blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation or PKD autophosphorylation. It also decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[6-amino-5-(6-ethoxy-2-naphthalenyl)-3-pyridinyl]-N-[2-(dimethylamino)ethyl]-benzamide, CRT0066051 |
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| Gene, Accession, CAS # | CAS: 1034297-58-9 |
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| Catalog # | LS-H7267 |
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| Price | |
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| Order / More Info | CRT5 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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