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| Product Name | JNJ-7777120 |
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| Description | Purity >97%. JNJ-7777120 is a potent and selective histamine H4 receptor antagonist, with a Ki value of approximately 4 nM against the human, mouse, and rat H4 receptors. Its Ki values for the histamine H1-3 receptors exceed 1 µM, regardless of species, and it has no or negligible effects on a range of other receptors and transporters. JNJ-777120 inhibits mast cell chemotaxis induced by 10 µM histamine (IC50 = 40 nM) and reduces neutrophil influx in mouse peritonitis models (10 mg/kg s.c.). It also impairs eosinophil and lymphocyte influx into airways during allergic airway inflammation. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (5-chloro-1H-indol-2-yl)(4-methyl-1-piperazinyl)-methanone |
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| Gene, Accession, CAS # | CAS: 459168-41-3 |
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| Catalog # | LS-H62 |
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| Order / More Info | JNJ-7777120 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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