| 产品详情 |
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| Product Name | TGX-221 |
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| Description | Purity >98%. Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of phosphatidylinositol at the 3 position to produce the second messengers phosphatidylinositol-3,4-bisphosphate (PtdIns-(3,4)-P2 ) and PtdIns-(3,4,5)-P3 . Class 1 PI3Ks are composed of a p110 catalytic subunit, of which there are 4 isoforms (p110Alpha, p110Beta, p110Delta, and p100Gamma), and a p85 regulatory subunit. TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110Beta. Inhibition appears to occur at the ATP binding site based on the observed increase in IC50 value from 5 to ~50 nM at ATP concentrations of 50 µM and 1 mM, respectively. TGX-221 inhibits PtdIns-(3,4)-P2 production in platelets with an IC50 value of 50 nM. Selective inhibition of PI3K p110Beta results in defective platelet thrombus formation and defines PI3K as a target for antithrombotic therapy. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 7-methyl-2-(4-morpholinyl)-9-[1-(phenylamino)ethyl]-4H-pyrido[1,2-a]pyrimidin-4-one |
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| Gene, Accession, CAS # | CAS: 663619-89-4 |
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| Catalog # | LS-H10188 |
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| Price | |
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| Order / More Info | TGX-221 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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