| 产品详情 |
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| Product Name | JQ1 (+/-) |
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| Description | Purity >98% by NMR, TLC. (±) JQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by (±) JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (6R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester |
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| Gene, Accession, CAS # | CAS: 1268524-69-1 |
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| Catalog # | LS-H14498 |
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| Price | |
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| Order / More Info | JQ1 (+/-) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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