| 产品详情 |
| Edit |   |
|---|
| Product Name | 6-thio-2'-Deoxyguanosine |
|---|
| Description | Purity >98%. 6-thio-2'-Deoxyguanosine (6-thio-dG) is a nucleoside analog that is incorporated into de novo -synthesized telomeres by telomerase. This induces telomerase dysfunction resulting in telomeric DNA damage and rapid cell death. This process occurs in cells expressing telomerase but not in telomerase-negative cells. DNA containing 6-thio-dG inhibits the function of RNase H, preventing the cleavage of DNA-RNA heteroduplexes. In mouse xenograft studies using A549 lung cancer cells, 6-thio-dG causes a decrease in tumor growth rate associated with telomere dysfunction. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 2'-deoxy-6-thio-guanosine, 6-thio-DG, NSC 71261, -Beta-Thioguanine deoxyriboside |
|---|
| Gene, Accession, CAS # | CAS: 789-61-7 |
|---|
| Catalog # | LS-H6257 |
|---|
| Price | |
|---|
| Order / More Info | 6-thio-2'-Deoxyguanosine from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|