| 产品详情 |
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| Product Name | Thyroid Hormone Receptor Antagonist (1-850) |
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| Description | Purity >97%. The activity of the thyroid hormones, L-thyroxine (T4) and 3,3',5-triiodo-L-thyronine (T3), is mediated by thyroid hormone nuclear receptors TR alpha and TR beta . Gene knockout studies in mice indicate that TR alpha modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TR beta plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary. Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TR alpha and TR beta (IC50s = 1.5 µM), demonstrating ~1,000-fold lower affinity for TR alpha in intact cells compared with T3. This compound is specific, showing no effect on the activity of the related retinoic acid receptor alpha . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[1-(4-nitrophenyl)-4-piperidinylidene]-acetic acid-2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide |
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| Gene, Accession, CAS # | CAS: 251310-57-3 |
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| Catalog # | LS-H132 |
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| Order / More Info | Thyroid Hormone Receptor Antagonist (1-850) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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