| 产品详情 |
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| Antigenic Specificity | CTNNB1 / Beta Catenin |
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| Clone | CTNNB1/2030R |
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| Host Species | Recombinant Rabbit |
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| Reactive Species | human |
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| Isotype | IgG |
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| Format | Protein A purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | IHC-Fx, PMA, SDS-PAGE, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CTNNB1 / Beta Catenin Antibody (clone CTNNB1/2030R) LS-C751115. Specificity: Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas. |
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| Immunogen | Recombinant full-length human beta-catenin protein. Antigen Molecular Weight: 92 kDa |
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| Other Names | CTNNB1, Beta-catenin, Catenin beta-1, CTNNB, Beta Catenin |
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| Gene, Accession # | CTNNB1, Gene ID: 1499 |
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| Catalog # | LS-C751115 |
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| Price | |
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| Order / More Info | CTNNB1 / Beta Catenin Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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