| 产品详情 |
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| Antigenic Specificity | LF / Lethal Factor |
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| Clone | LFA58 |
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| Host Species | Mouse |
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| Reactive Species | bacillus anthracis |
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| Isotype | IgG1 |
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| Format | affinity purified |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | ELISA, WB |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LF / Lethal Factor Antibody (clone LFA58) LS-C58344. Recognizes the Lethal Factor of the anthrax toxin. Bacillus anthracis produces a toxin composed of three proteins, the Protective Antigen (PA), the Edema Factor (EF) and the Lethal Factor (LF). The three proteins depend on each other for their toxic effect. Both EF and LF functions intracellularly but are too large to enter the cell through existing channels. The PA is responsible for transporting the EF and LF into cells. The LF acts as an endoprotease, removing the N-terminus of mitogen-activated protein kinase kinases (MAPKK). The kinases are prevented from binding to their substrates, which leads to altered signalling pathways and ultimately to apoptosis. May be used as a capture antibody in ELISA assays for the Lethal Factor of Bacillus anthracis. |
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| Immunogen | Highly purified Bacillus anthracis lethal factor. |
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| Other Names | lef, Lethal Factor, LF |
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| Gene, Accession # | lef |
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| Catalog # | LS-C58344 |
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| Price | |
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| Order / More Info | LF / Lethal Factor Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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