| 产品详情 |
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| Antigenic Specificity | CD276 / B7-H3, aa1-242 |
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| Clone | MJ18 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | Flo (1:25 - 1:200), Func |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD276 / B7-H3 Antibody (aa1-242, clone MJ18, Low Endotoxin) LS-C188633. Recognizes mouse CD276, otherwise known as B7-H3, a ubiquitously expressed transmembrane glycoprotein and member of the B7 family of co-stimulatory molecules, which acts as both a positive and negative regulator of T-cell-mediated immune responses. CD276 is highly expressed in bone during embryogenesis, and can be induced on dendritic cells and monocytes by inflammatory cytokines. CD276 has been implicated in the development of acute and chronic transplant rejection, and is reported to have therapeutic potential as a regulator of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy. In mice, CD276 has been linked with the development of pathogenic Th2 cells during the induction phase of allergic asthma. Studies have shown that clone MJ18 inhibits stimulated CD4+ T-cell proliferation. |
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| Immunogen | Mouse IgG2a Fc-CD276 (aa 1-242). |
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| Other Names | CD276, 4Ig-B7-H3, B7 homolog 3, B7-H3, CD276 antigen, CD276 molecule, Costimulatory molecule, B7H3, B7RP-2 |
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| Gene, Accession # | CD276, Gene ID: 80381 |
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| Catalog # | LS-C188633 |
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| Price | |
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| Order / More Info | CD276 / B7-H3, aa1-242 Antibody from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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