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| Product Name | Human CD274 / B7-H1 / PD-L1 Protein (Recombinant) |
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| Description | Purity >95% by SDS-PAGE gel and HPLC analyses., MW: 102.6 kDa or 160-170 kDa. Programmed death-ligand 1 (PD-L1), or B7-H1, is a transmembrane, co-stimulatory ligand of programmed cell death protein 1 (PD-1) that, along with B7-1 and B7-2, belongs to the B7 family and immunoglobulin superfamily. Though more notably expressed on activated T-cells, B-cells, myeloid cells, and a subset of thymocytes, PD-L1 is also expressed constitutively by nonlymphoid, parenchymal organs, including the heart, placenta, skeletal muscle, and lung; with the marked exception of the small intestine. As a member of the B7 family, PD-L1 plays a principal role in immunity: suppressing immune response against autoantigens and tumors, maintaining T-cell homeostasis, maintaining peripheral immune tolerance, and regulating T-cell-mediated cytokine secretion. Unlike B7-1 and B7-2, PD-L1 has not been shown to influence immunity through interaction with CD28, CTL4A or ICOS, but rather through interaction with PD-1, a weak structural homolog of CTLA4 that belongs to the same superfamily. Involvement of PD-1 suggests an inhibitory function during T-cell activation; however, evidence has demonstrated PD-L1's conflicting responsibility for both the stimulation and inhibition of T-cell-mediated cytokine synthesis. While T-cell co-stimulation with PD-L1 induces proliferation and the secretion of IL-10 and IFN-?, muscle cell expression of PD-L1 has been shown to inhibit function of CD4 and CD8 T-cells by down-regulating cytokine secretion and the expression of T-cell activation markers. Augmented expression of PD-L1 has been linked to the inhibition of antitumor immune response in cancer, and the up-regulation of IL-10 production in HIV-infection, resulting in increased susceptibility of antigen-specific T-cells to apoptosis. PeproTech's CHO cell-derived Recombinant Human PD-L1 Fc is a glycosylated, disulfide-linked homodimer of 906 amino acid residues whose monomer consists of the 220-amino-acid length extracellular portion of PD-L1 fused to the 231-amino-acid length Fc portion of human IgG1 by two glycines. The calculated molecular weight of CHO cell-derived Recombinant Human PD-L1 Fc is 102.6 kDa, however, due to glycosylation, it migrates at an apparent molecular weight of approximately 160-170 kDa by SDS-PAGE analysis under non-reducing conditions. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD274, B7-H, B7 homolog 1, B7-H1, B7H1, CD274 molecule, CD274 antigen, PDCD1 ligand 1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, Programmed death ligand 1 |
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| Gene, Accession, CAS # | CD274, Gene ID: 29126 |
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| Catalog # | LS-G133816 |
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| Order / More Info | Human CD274 / B7-H1 / PD-L1 Protein (Recombinant) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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